Gigi Berardi, a Western Washington University environmental science professor and award-winning writer who has taught in Italy for 15 years, talks about her historical fiction novel Bianca’s Cure. Gigi explains choosing the Medici because their patronage shaped Florence and because her book centers on the “greatest mystery of the Renaissance”: the near-simultaneous deaths of Grand Duke Francesco de’ Medici and his wife Bianca Cappello, debated as arsenic poisoning, malaria, or murder by his brother Ferdinando. She describes building an accurate historical “skeleton” from primary sources and extensive fact-checking with Florence researchers while inventing plausible internal monologue using tonal exercises. The conversation covers Bianca’s Venetian aristocratic background, Renaissance medicine and Artemisia/antimalarial history, women’s roles in alchemy, Florence as a character, and Gigi’s view of success as visibility and reader engagement.